Professor van Smeden's work has resulted in publications in well-renowned journals in the field of medical statistics (e.g. Statistics in Medicine), epidemiology (e.g. American journal of Epidemiology), and general medicine (e.g. BMJ). As a collaborator, he has also contributed to implementing advanced methodology in a variety of disciplines (e.g. cardiology, infectious diseases, general practice). He is also associate editor at the European Heart Journal and Diagnostic and Prognostic Research (BMC journals) and has been involved in the development and validation of numerous diagnostic and prognostic prediction models.